Straus D J
Lymphoma Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 406, New York, NY 10021, USA.
Curr Oncol Rep. 2001 May;3(3):260-5. doi: 10.1007/s11912-001-0059-7.
Intermediate and high-grade non-Hodgkin lymphomas (NHL) with a B-cell phenotype are AIDS-defining illnesses. The incidence of systemic NHL is over 100 times increased, primary central nervous system NHL is over 3000 times increased, and Hodgkin's disease is approximately 10 times increased in the HIV-infected population. Unusual extranodal presentations of NHL and Hodgkin's disease are seen in HIV-infected individuals. High-grade histologies are common for both NHL and Hodgkin's disease in the HIV setting. Treatment approaches may be changing with the advent of highly active antiretroviral therapy, which may allow patients to tolerate more intensive treatment.
具有B细胞表型的中高级别非霍奇金淋巴瘤（NHL）是艾滋病界定疾病。在感染HIV的人群中，系统性NHL的发病率增加了100多倍，原发性中枢神经系统NHL的发病率增加了3000多倍，霍奇金病的发病率增加了约10倍。在感染HIV的个体中可见NHL和霍奇金病不寻常的结外表现。在HIV感染情况下，NHL和霍奇金病的高级别组织学类型都很常见。随着高效抗逆转录病毒疗法的出现，治疗方法可能正在发生变化，这可能使患者能够耐受更强化的治疗。
