Spina M, Tirelli U, Zagonel V, Gloghini A, Volpe R, Babare R, Abbruzzese L, Talamini R, Vaccher E, Carbone A
Division of Medical Oncology and AIDS, Centro di Riferimento Oncologico, Aviano, Italy.
Cancer. 1998 Feb 15;82(4):766-74.
Burkitt's lymphoma (BL) accounts for 1-2% of all cases of non-Hodgkin's lymphoma (NHL) in the general population and for 35-40% in the setting of human immunodeficiency virus (HIV) infection. The authors report a 9-year single-institution experience with 75 adult BL patients (46 with and 29 without HIV infection) and compare the clinical and pathologic features of the disease in the two groups of patients.
Between May 1987 and June 1995, 131 patients with HIV infection and systemic NHL were diagnosed and treated at the National Cancer Institute in Aviano, Italy. In 46 cases (35%), the diagnosis was BL. During the same period, 29 of 1004 HIV negative NHL patients (2.8%) were diagnosed with BL and treated at the same institution.
No statistical differences were found in the general characteristics of the two groups at the time that BL was diagnosed. Complete response rate was significantly lower for patients with HIV infection than for those without HIV infection (40% vs. 65%, P = 0.03). The median overall survival was significantly shorter for patients with HIV infection (7 months vs. not yet reached, P = 0.0001). However, the disease free survival (DFS) at 4 years was identical for the two groups of patients (74% for HIV positive patients vs. 73% for HIV negative patients, P = 0.70).
The data from this study show that patients with BL with and without HIV infection share similar clinicopathologic characteristics at presentation. Although the median overall survival is significantly shorter for patients with HIV infection, the DFS is identical for both groups.
伯基特淋巴瘤（BL）在普通人群的非霍奇金淋巴瘤（NHL）病例中占1% - 2%，而在人类免疫缺陷病毒（HIV）感染患者中占35% - 40%。作者报告了在一家机构对75例成年BL患者（46例合并HIV感染，29例未合并HIV感染）进行的9年研究经验，并比较了两组患者该疾病的临床和病理特征。
1987年5月至1995年6月期间，意大利阿维亚诺国家癌症研究所对131例合并HIV感染的系统性NHL患者进行了诊断和治疗。其中46例（35%）诊断为BL。同期，1004例HIV阴性的NHL患者中有29例（2.8%）在同一机构被诊断为BL并接受治疗。
在诊断为BL时，两组患者的一般特征未发现统计学差异。合并HIV感染患者的完全缓解率显著低于未合并HIV感染的患者（40%对65%，P = 0.03）。合并HIV感染患者的中位总生存期显著缩短（7个月对未达到，P = 0.0001）。然而，两组患者4年无病生存期（DFS）相同（HIV阳性患者为74%对HIV阴性患者为73%，P = 0.70）。
本研究数据表明，合并和未合并HIV感染的BL患者在初诊时具有相似的临床病理特征。尽管合并HIV感染患者的中位总生存期显著缩短，但两组的DFS相同。
