Northfelt D W, Kaplan L D
Division of AIDS Activities/Oncology, University of California, San Francisco.
Cancer Surv. 1991;10:121-33.
Non-Hodgkin lymphoma developing in patients with HIV infection fulfills diagnostic criteria for AIDS. Clinical manifestations of AIDS-NHL are similar to those of malignant lymphoma arising in other acquired and congenital immunodeficiency states. AIDS related NHLs therefore consist primarily of tumours with B cell phenotype, intermediate or high grade histological subtype and rapid clinical progression with a high frequency of unusual extranodal involvement. Treatment of AIDS-NHL has been much less rewarding than treatment of lymphoma in non-HIV infected individuals. Complete response rates are lower than the corresponding rates seen in the non-HIV infected population, and responses that do occur tend to be of short duration. Improvements in treatment for AIDS-NHL will require the use of new therapies, designed to cause less myelosuppression, in conjunction with aggressive efforts to prevent opportunistic infections.
感染HIV的患者所患的非霍奇金淋巴瘤符合艾滋病的诊断标准。艾滋病相关非霍奇金淋巴瘤的临床表现与其他获得性和先天性免疫缺陷状态下发生的恶性淋巴瘤相似。因此，艾滋病相关非霍奇金淋巴瘤主要由具有B细胞表型、组织学亚型为中或高级别且临床进展迅速、结外受累异常频繁的肿瘤组成。与非HIV感染个体的淋巴瘤治疗相比，艾滋病相关非霍奇金淋巴瘤的治疗效果要差得多。完全缓解率低于非HIV感染人群的相应缓解率，而且即便出现缓解，持续时间往往也很短。要改善艾滋病相关非霍奇金淋巴瘤的治疗，需要使用旨在减少骨髓抑制的新疗法，并积极努力预防机会性感染。
