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[氯乙烯和1,2 - 二氯乙烷:致癌性分类与评估、指南、阈值以及国家和国际实体、组织及机构制定的标准]

[Vinyl chloride and 1,2-dichloroethane: classification and assessment of carcinogenicity, guidelines, threshold values, and standards developed by national and international entities, organizations, and agencies].

作者信息

Binetti R, Costamagna F M, Marcello I

机构信息

Istituto superiore di sanità, Laboratorio di tossicologia applicata, Inventario nazionale delle sostanze chimiche, Roma.

出版信息

Epidemiol Prev. 2001 Jan-Feb;25(1):31-9.

PMID:11296535
Abstract

International, national and regulatory classification, evaluation, guidelines and occupational exposure values regarding vinyl chloride and 1,2-dichloroethane, carried out by European Union (EU). Environmental Protection Agency (US EPA), International Agency for Research on Cancer (IARC), Italian National Advisory Toxicological Committee (CCTN), Occupational Safety and Health Administration (OSHA), World Health Organization (WHO), National Institute for Occupational Safety and Health (NIOSH), American Conference of Governmental Industrial Hygienists (ACGIH) and other institutions, have been considered with particular reference to the carcinogenic effects. Moreover information is reported in support of classification and evaluation and a short historical review since early 1970s, when first evidence that occupational exposure to VC could lead to angiosarcoma was published.

摘要

欧盟(EU)、美国环境保护局(US EPA)、国际癌症研究机构(IARC)、意大利国家毒理学咨询委员会(CCTN)、职业安全与健康管理局(OSHA)、世界卫生组织(WHO)、美国国家职业安全与健康研究所(NIOSH)、美国政府工业卫生学家会议(ACGIH)及其他机构对氯乙烯和1,2 - 二氯乙烷进行的国际、国家和法规分类、评估、指南及职业接触限值,已特别参考致癌效应进行了审议。此外,还报告了支持分类和评估的信息以及自20世纪70年代初以来的简短历史回顾,当时首次发表了职业接触氯乙烯可导致血管肉瘤的证据。

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