Vantaux P, Schneider P, Le Coz S, Villers A
Service de Médecine Interne, Centre Hospitalier Inter Communal Castres-Mazamet, 20, Boulevard du Maréchal Foch, 81100 Castres.
Prog Urol. 2001 Feb;11(1):68-9.
Prostate cancer can be complicated by disseminated intravascular coagulation. The severity of this complication justifies rapid medical treatment. The authors describe the case of a man in his seventies presenting with disseminated purpuric lesions due to disseminated intravascular coagulation. Prostate cancer was documented concomitantly. The clinical course was rapidly unfavourable despite endocrine therapy and blood transfusions. The mechanism of disseminated intravascular coagulation in prostate cancer has not been clearly elucidated, but appears to be related to release of procoagulant substances during certain diagnostic or therapeutic procedures. The severity of the prognosis justifies rapid introduction of endocrine therapy, which is not immediately effective. It can help to achieve a period of remission if the haemorrhagic syndrome is controlled. Further studies may help to improve therapeutic management.
前列腺癌可并发弥散性血管内凝血。这种并发症的严重性使得迅速进行医学治疗成为必要。作者描述了一名七十多岁男性的病例,该患者因弥散性血管内凝血出现弥散性紫癜性病变。同时确诊患有前列腺癌。尽管进行了内分泌治疗和输血,临床病程仍迅速恶化。前列腺癌中弥散性血管内凝血的机制尚未完全阐明,但似乎与某些诊断或治疗过程中促凝物质的释放有关。预后的严重性使得迅速引入内分泌治疗成为必要,尽管其并非立即有效。如果出血综合征得到控制,它有助于实现一段缓解期。进一步的研究可能有助于改善治疗管理。