Natkunam Y, Warnke R A
Department of Pathology, Stanford University Medical Center, CA 94305, USA.
Semin Diagn Pathol. 2001 Feb;18(1):67-77.
Angiocentric lymphomas are a heterogeneous spectrum of hematolymphoid malignancies that share a particular histologic characteristic, namely, an angiocentric or perivascular growth pattern. They include a variety of T-, B-, and natural killer-cell derived lymphomas that digress in many clinicopathologic features, immunophenotype, and prognosis. The term angiocentric lymphomas was initially used to refer to natural killer and natural killer-like T-cell lymphomas that show a prominent angiocentric growth pattern. With better immunophenotypic and molecular characterization together with evolving knowledge regarding their biology and pathogenesis, these lymphomas have now been reclassified. Apart from morphology, many features pertinent to the diagnosis of natural killer and natural killer-like T-cell lymphomas are shared by other peripheral T-cell and B-cell lymphomas, and by a subset of leukemias. The salient clinicopathologic features of natural killer and natural killer-like T-cell lymphomas together with the inherent difficulty of their identification and an integrated approach to their diagnosis are outlined in this article.
血管中心性淋巴瘤是一类异质性的血液淋巴系统恶性肿瘤，它们具有一个共同的特殊组织学特征，即血管中心性或血管周围生长模式。它们包括多种源自T细胞、B细胞和自然杀伤细胞的淋巴瘤，这些淋巴瘤在许多临床病理特征、免疫表型和预后方面存在差异。血管中心性淋巴瘤这一术语最初用于指代表现出显著血管中心性生长模式的自然杀伤细胞和自然杀伤样T细胞淋巴瘤。随着免疫表型和分子特征的更好鉴定以及对其生物学和发病机制认识的不断发展，这些淋巴瘤现在已被重新分类。除形态学外，自然杀伤细胞和自然杀伤样T细胞淋巴瘤诊断相关的许多特征也为其他外周T细胞和B细胞淋巴瘤以及一部分白血病所共有。本文概述了自然杀伤细胞和自然杀伤样T细胞淋巴瘤的显著临床病理特征、识别它们的固有困难以及综合诊断方法。
