Uni Z, Gal-Garber O, Geyra A, Sklan D, Yahav S
Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Animal Sciences, Rehovot, Israel.
Poult Sci. 2001 Apr;80(4):438-45. doi: 10.1093/ps/80.4.438.
The effect of exposure to heat at 3 d of age on small intestine functionality and development was assayed by measuring villus size, proliferating enterocytes, and brush-border membrane (BBM) enzyme expression and activity. Results showed that thermal conditioning caused an immediate effect characterized by lowered triiodothyronine (T3) level, reduced feed intake, and depressed enterocyte proliferation and BBM enzyme activity. A second series of effects, observed 48 h posttreatment, was characterized by elevated T3, increased feed intake, increased enterocyte proliferation, and higher expression and activity of BBM enzymes. The association between ambient temperature, feed intake, growth rate, and plasma T3 levels was reflected in the structure and function of the intestinal tract. The results suggest that thermal conditioning at an early age influences T3 concentrations, which in turn alter the intestinal capacity to proliferate, grow, and digest nutrients. However, these experiments were not able to discriminate between effects due to feed intake and those due to thermal conditioning. The treatments modulated changes in the intestinal tract following thermal treatment.
通过测量绒毛大小、增殖肠上皮细胞以及刷状缘膜（BBM）酶的表达和活性，来测定3日龄时受热对小肠功能和发育的影响。结果显示，热调节产生了即时效应，其特征为三碘甲状腺原氨酸（T3）水平降低、采食量减少、肠上皮细胞增殖和BBM酶活性受到抑制。在处理后48小时观察到的第二系列效应，其特征为T3升高、采食量增加、肠上皮细胞增殖增加以及BBM酶的表达和活性更高。环境温度、采食量、生长速率和血浆T3水平之间的关联反映在肠道的结构和功能上。结果表明，早期热调节会影响T3浓度，进而改变肠道增殖、生长和消化营养物质的能力。然而，这些实验无法区分采食量造成的影响和热调节造成的影响。这些处理调节了热处理后肠道的变化。
