Henkel B, Bayer E
Morphochem AG, München, Germany.
J Pept Sci. 2001 Mar;7(3):152-6. doi: 10.1002/psc.309.
This paper presents a new protecting group, the (2-nitrofluoren-9-yl)methoxycarbonyl group. Investigations on the properties of this new modification of the Fmoc-system, such as the solvent-dependent photochemical cleavage, and enhanced lability towards bases, are described, as well as UV-kinetic measurements of the cleavage reaction. In addition, the incorporation of the (2-nitrofluoren-9-yl)methoxycarbonyl group into two peptides, and a sequence-dependent photochemical cleavage reaction are reported.
本文介绍了一种新的保护基团，即（2-硝基芴-9-基）甲氧基羰基基团。描述了对Fmoc体系这种新修饰的性质的研究，如溶剂依赖性光化学裂解以及对碱的增强不稳定性，还介绍了裂解反应的紫外动力学测量。此外，还报道了将（2-硝基芴-9-基）甲氧基羰基基团引入两种肽以及序列依赖性光化学裂解反应。
