Hartman Alison E, Brophy Cheryl L, Cupp Julia A, Hodge Daniel K, Peelen Timothy J
Department of Chemistry, Lebanon Valley College, Annville, Pennsylvania 17003, USA.
J Org Chem. 2009 May 15;74(10):3952-4. doi: 10.1021/jo8027714.
Weakly basic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound. The new reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction conditions and should serve as a model for the development of more efficient syntheses of Fmoc-protected amino acids.
弱碱性碳亲核试剂能有效地加成到Fmoc保护的N,O-缩醛化合物上。这些新反应突出了Fmoc保护基团与中等碱性反应条件的兼容性，应为开发更高效合成Fmoc保护氨基酸的方法提供范例。
