Harris C A, Woolridge M W, Hay A W
Pesticides Safety Directorate, Mallard House, York, UK.
Chemosphere. 2001 Apr;43(2):243-56. doi: 10.1016/s0045-6535(00)00149-1.
Existing studies monitoring organochlorine pesticide residues in breastmilk were examined to identify whether common factors determine the extent of transfer of these residues. A structured review of the English language literature was conducted. Papers were reviewed and assessed using a structured protocol. A total of 77 papers were initially identified, 46 of which contained conclusions relating to the factors which may affect the transfer of residues into breastmilk. Owing to the diversity of findings, papers were screened further to include only those in which a minimum of background information relating to selection of mothers and to milk sampling procedures were reported. Only eight papers were deemed to contain adequate information. Age, parity/length of previous lactation, fat mobilisation and the time of sampling were identified as the most likely factors to be considered when assessing transfer of organochlorine pesticide residues into breastmilk. This review highlights the difficulties of assessing trends in breastmilk contaminants where comparable sampling procedures are not used.
对现有的监测母乳中有机氯农药残留的研究进行了审查，以确定是否存在共同因素决定这些残留物的转移程度。对英文文献进行了结构化综述。使用结构化方案对论文进行审查和评估。最初共识别出77篇论文，其中46篇包含与可能影响残留物向母乳转移的因素相关的结论。由于研究结果的多样性，对论文进行了进一步筛选，只纳入那些至少报告了与母亲选择和乳汁采样程序相关的背景信息的论文。只有8篇论文被认为包含足够的信息。年龄、产次/既往哺乳时长、脂肪动员和采样时间被确定为评估有机氯农药残留向母乳转移时最有可能需要考虑的因素。本综述强调了在未采用可比采样程序的情况下评估母乳污染物趋势的困难。
