Wang Rong, Metayer Catherine, Morimoto Libby, Wiemels Joseph L, Yang Juan, DeWan Andrew T, Kang Alice, Ma Xiaomei
Am J Epidemiol. 2017 Oct 1;186(7):843-856. doi: 10.1093/aje/kwx160.
Linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born during 1978-2009 to investigate the relationship of parental age to risk of pediatric cancer. Compared with children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13%-36% higher risk of pediatric cancer; the odds ratio for each 5-year increase in maternal age was 1.06 (95% confidence interval (CI): 1.04, 1.09). For cancer diagnosed in children in age groups 0-14 years and 15-19 years, the odds ratios for each 5-year increase in maternal age were 1.05 (95% CI: 1.02, 1.07) and 1.14 (95% CI: 1.09, 1.19), respectively. Having an older father also conferred an increased risk, with an odds ratio for each 5-year increase of 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-19 years and 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-14 years. While advancing maternal age increased risk of leukemia and central nervous system tumors, older paternal age was not associated with risk of either type. Both maternal and paternal older ages were associated with risk of lymphoma. In this large, population-based record-linkage study, advancing parental age, especially advancing maternal age, was associated with higher pediatric cancer risk, with variations across types of cancer.
通过将加利福尼亚州的出生记录与癌症登记数据相链接，我们开展了一项基于人群的研究，研究对象为1978年至2009年期间出生的23419例病例和87593例匹配对照，以调查父母年龄与儿童癌症风险之间的关系。与20至24岁母亲所生的孩子相比，年龄较大组母亲所生的孩子患儿童癌症的风险高13%至36%；母亲年龄每增加5岁，比值比为1.06（95%置信区间（CI）：1.04，1.09）。对于0至14岁和15至19岁年龄组儿童诊断出的癌症，母亲年龄每增加5岁的比值比分别为1.05（95%CI：1.02，1.07）和1.14（95%CI：1.09，1.19）。父亲年龄较大也会增加风险，0至19岁诊断出癌症时，父亲年龄每增加5岁的比值比为1.03（95%CI：1.02，1.05），0至14岁诊断出癌症时为1.03（95%CI：1.02，1.05）。虽然母亲年龄增长会增加白血病和中枢神经系统肿瘤的风险，但父亲年龄较大与这两种类型的风险均无关。父母年龄较大均与淋巴瘤风险有关。在这项基于人群的大型记录链接研究中，父母年龄增长，尤其是母亲年龄增长，与儿童癌症风险较高有关，且不同癌症类型存在差异。
