Elvin-Lewis M
Department of Biology, Washington University, Box 1137, St. Louis, MO 63130-4899, USA.
J Ethnopharmacol. 2001 May;75(2-3):141-64. doi: 10.1016/s0378-8741(00)00394-9.
During the latter part of this century the practice of herbalism has become mainstream throughout the world. This is due in part to the recognition of the value of traditional medical systems, particularly of Asian origin, and the identification of medicinal plants from indigenous pharmacopeias that have been shown to have significant healing power, either in their natural state or as the source of new pharmaceuticals. Generally these formulations are considered moderate in efficacy and thus less toxic than most pharmaceutical agents. In the Western world, in particular, the developing concept that 'natural' is better than 'chemical' or 'synthetic' has led to the evolution of Neo-Western herbalism that is the basis of an ever expanding industry. In the US, often guised as food, or food supplements, known as nutriceuticals, these formulations are readily available for those that wish to self-medicate. Within this system, in particular, are plants that lack ethnomedical verification of efficacy or safety. Unfortunately there is no universal regulatory system in place that insures that any of these plant remedies are what they say they are, do what is claimed, or most importantly are safe. Data will be presented in this context, outlining how adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life-threatening or lethal.
在本世纪后期,草药疗法在全球已成为主流。部分原因在于人们认识到传统医学体系的价值,尤其是源自亚洲的传统医学体系,以及从本土药典中鉴定出的药用植物,这些植物已被证明无论是在自然状态下还是作为新药物的来源,都具有显著的治疗能力。一般来说,这些制剂的疗效被认为适中,因此毒性比大多数药物制剂小。特别是在西方世界,“天然”优于“化学”或“合成”这一不断发展的观念导致了新西方草药疗法的演变,这是一个不断扩张的产业的基础。在美国,这些制剂常常被伪装成食品或食品补充剂,即所谓的营养药品,对于那些希望自我药疗的人来说很容易获得。在这个体系中,尤其存在一些缺乏疗效或安全性的民族医学验证的植物。不幸的是,目前没有一个通用的监管体系来确保这些植物疗法中的任何一种名副其实、达到宣称的效果,或者最重要的是确保其安全性。将在本文中呈现相关数据,概述掺假、不当配方或对植物与药物相互作用的理解不足是如何导致有时危及生命或致命的不良反应的。