Sadek S A, De R, Scott A, White A P, Wilson P S, Carlin W V
Department of Otolaryngology/Head and Neck Surgery, City General Hospital, Stoke-on-Trent, Staffordshire, UK.
Clin Otolaryngol Allied Sci. 2001 Feb;26(1):25-8. doi: 10.1046/j.1365-2273.2001.00400.x.
The routine use of topical anaesthesia during flexible nasendoscopy has been questioned, and the degree to which topical vasoconstrictors can affect patient discomfort has yet to be elucidated. Patients' experiences with Lignocaineand phenylephrine, Lignocaine alone, xylometazoline and no preparation were compared. One hundred patients were recruited in this double-blind, randomised control trial and put into these four groups. Each patient completed a visual analogue scoring chart to determine the severity of unpleasantness and other undesirable effects (pain, bad taste, burning, choking, numbness and difficulty in swallowing). The results confirmed that vasoconstriction is a major contributing factor towards reducing overall unpleasantness (P = 0.022), topical anaesthesia can produce a bad taste (P = 0.022), and that none of the preparations have any effect on the pain during nasendoscopy. In conclusion, xylometazoline is recommended for nasendoscopy as it is effective and is significantly cheaper than the other preparations. Not using any preparations leads to the experience of severe symptoms.
在可弯曲鼻内镜检查期间常规使用局部麻醉受到了质疑，局部血管收缩剂对患者不适的影响程度尚待阐明。比较了患者使用利多卡因和去氧肾上腺素、单独使用利多卡因、赛洛唑啉以及不做任何预处理的体验。在这项双盲随机对照试验中招募了100名患者并将其分为这四组。每位患者完成一份视觉模拟评分表，以确定不适感和其他不良影响（疼痛、异味、灼烧感、呛咳、麻木和吞咽困难）的严重程度。结果证实，血管收缩是减轻总体不适感的主要因素（P = 0.022），局部麻醉会产生异味（P = 0.022），并且没有一种预处理对鼻内镜检查期间的疼痛有任何影响。总之，推荐使用赛洛唑啉进行鼻内镜检查，因为它有效且比其他预处理显著便宜。不做任何预处理会导致出现严重症状。
