3-碘-2-丙炔醇丁基氨甲酸酯（IPBC）引起的过敏性接触性皮炎——最新进展

Allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate (IPBC) - an update.

作者信息

Bryld L E, Agner T, Menné T

机构信息

Department of Dermatology, Gentofte University Hospital, 2900 Hellerup, Denmark.

出版信息

Contact Dermatitis. 2001 May;44(5):276-8. doi: 10.1034/j.1600-0536.2001.440504.x.

DOI:10.1034/j.1600-0536.2001.440504.x

PMID:11298692

Abstract

Results from 3 1/2 years of routine patch testing with 3-iodo-2-propynyl-butylcarbamate (IPBC) are presented. From 1996 to 1999, a total of 3168 persons (2093 women and 1075 men) were patch tested with IPBC, and 7 cases were found to be positive. In 2 cases, sensitization could be attributed to cosmetics, and in a further 2 cases cosmetics were the most likely cause of sensitisation. It is concluded that the use of IPBC in cosmetic products can lead to contact sensitization and allergic contact dermatitis. 2 of the 7 reported cases with IPBC allergy were also found positive to thiuram, and possible cross-reactivity between IPBC and thiuram is discussed.

摘要

本文展示了3.5年以来对3-碘-2-丙炔醇丁基氨甲酸酯（IPBC）进行常规斑贴试验的结果。1996年至1999年期间，共有3168人（2093名女性和1075名男性）接受了IPBC斑贴试验，其中7例呈阳性。在2例中，致敏可归因于化妆品，另有2例中化妆品最有可能是致敏原因。得出的结论是，化妆品中使用IPBC可导致接触致敏和过敏性接触性皮炎。在7例报告的IPBC过敏病例中，有2例对秋兰姆也呈阳性，文中讨论了IPBC与秋兰姆之间可能的交叉反应。