Dermatitis. 2010 Nov-Dec;21(6):303-10.
iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products.
to evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America.
the North American Contact Dermatitis Group (NACDG) tested IPBC 0.1% and/or 0.5% in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated.
of the 25,321 patients tested, there were 226 (0.9%) weak reactors and 67 (0.3%) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (> 50%) of currently relevant reactions were to personal care products, and most reactions (> 90%) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2% vs 1.5%) when the higher concentration of IPBC was utilized, but most (> 64%) were weak reactions, of which some were likely irritant.
allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5% pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.
碘丙炔醇丁基氨甲酸酯（IPBC）是一种常用的防腐剂，存在于工业和个人护理产品中。
评估北美患者中 IPBC 的流行率、临床相关性、职业关联性和阳性反应来源。
1998 年至 2008 年期间，北美接触性皮炎组（NACDG）使用 IPBC0.1%和/或 0.5%的凡士林（pet）进行测试。根据 IPBC 斑贴试验反应，定义了两组感兴趣的患者：弱（+）反应者和强（++或 +++）反应者。列出了患者特征、皮炎部位、阳性反应源、临床相关性和职业相关性 IPBC。
在 25321 名接受测试的患者中，有 226 名（0.9%）弱反应者和 67 名（0.3%）强反应者。对于 IPBC 阳性患者，最常见的皮炎部位是散在的全身分布、手部和手臂。目前大多数（>50%）相关反应是针对个人护理产品，而且大多数（>90%）反应与职业无关。仅有 4 名强反应者具有明确的临床相关性（含有 IPBC 的产品的阳性使用测试反应或阳性斑贴试验反应）。当使用更高浓度的 IPBC 时，阳性反应的频率增加（0.2%对 1.5%），但大多数（>64%）是弱反应，其中一些可能是刺激性的。
对 IPBC 的过敏相对少见。当具有临床相关性时，个人护理产品是最有可能的过敏原来源。由于 IPBC 是一种边缘刺激性物质，在使用更高浓度的 IPBC（≥0.5%pet）和解释弱（+）反应时应谨慎。通过使用测试或重复斑贴测试或两者结合来验证临床相关性也很重要。
