Chagnon Y C, Rice T, Pérusse L, Borecki I B, Ho-Kim M A, Lacaille M, Paré C, Bouchard L, Gagnon J, Leon A S, Skinner J S, Wilmore J H, Rao D C, Bouchard C
Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste. Foy, Quebec, Canada G1K 7P4.
J Appl Physiol (1985). 2001 May;90(5):1777-87. doi: 10.1152/jappl.2001.90.5.1777.
An autosomal genomewide search for genes related to body composition and its changes after a 20-wk endurance-exercise training program has been completed in the HERITAGE Family Study. Phenotypes included body mass index (BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass, percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families was studied with the use of 344 markers with single-point and multipoint linkage analyses. Evidence of significant linkage was observed for changes in fat-free mass with the S100A and the insulin-like growth factor I genes (P = 0.0001). Suggestive evidence (2.0 < or = Lod < 3.0; 0.0001 < P < or = 0.001) was also observed for the changes in FM and %Fat at 1q31 and 18q21-q23, in %Fat with the uncoupling protein 2 and 3 genes, and in BMI at 5q14-q21. At baseline, suggestive evidence was observed for BMI at 8q23-q24, 10p15, and 14q11; for FM at 14q11; and for plasma leptin levels with the low-density lipoprotein receptor gene. This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss.
