Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center , Dallas, Texas ; Transplant Research Program, Boston Children's Hospital , Boston, Massachusetts ; Department of Pediatrics, Harvard Medical School , Boston, Massachusetts ; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval , Québec , Canada ; and Centre de Recherche sur le Cancer de l'Université Laval, Université Laval , Québec , Canada.
Physiol Rev. 2018 Jul 1;98(3):1765-1803. doi: 10.1152/physrev.00064.2017.
DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a kinase at the center of two important protein complexes named mTORC1 and mTORC2. These highly studied complexes play essential roles in regulating growth, metabolism, and immunity in response to mitogens, nutrients, and cytokines. Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches aiming at modulating mTOR activity are envisioned as an attractive strategy to improve human health. DEPTOR interaction with mTOR represses its kinase activity and rewires the mTOR signaling pathway. Over the last years, several studies have revealed key roles for DEPTOR in numerous biological and pathological processes. Here, we provide the current state of the knowledge regarding the cellular and physiological functions of DEPTOR by focusing on its impact on the mTOR pathway and its role in promoting health and disease.
DEP 结构域包含肌醇依赖的蛋白激酶 3 相互作用蛋白（DEPTOR）是 mTOR 的重要调节因子，mTOR 是位于两个重要蛋白复合物中心的激酶，分别命名为 mTORC1 和 mTORC2。这些高度研究的复合物在调节生长、代谢和免疫方面发挥着重要作用，以响应有丝分裂原、营养物质和细胞因子。mTOR 信号的缺陷与许多疾病的发展有关，包括癌症和糖尿病，并且调节 mTOR 活性的方法被设想为改善人类健康的一种有吸引力的策略。DEPTOR 与 mTOR 的相互作用抑制其激酶活性并重新构建 mTOR 信号通路。在过去的几年中，多项研究揭示了 DEPTOR 在许多生物学和病理学过程中的关键作用。在这里，我们通过关注其对 mTOR 途径的影响及其在促进健康和疾病中的作用，提供了关于 DEPTOR 的细胞和生理功能的最新知识状态。
