Krymchantowski A V, Barbosa J S, Cheim C, Alves L A
Headache Center of Rio, Rio de Janeiro, Brazil.
Arq Neuropsiquiatr. 2001 Mar;59(1):46-9. doi: 10.1590/s0004-282x2001000100010.
Several oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective to treat migraine attacks. Lysine clonixinate (LC) is a NSAID derived from nicotinic acid that has proven to be effective in various pain syndromes such as renal colic and muscular pain. The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of oral LC compared to placebo in the acute treatment of migraine. Sixty four patients with the diagnosis of migraine, according to the IHS criteria, were studied prospectively. Patients received LC or placebo once the headache reached moderate or severe intensity for 6 consecutive attacks. With regard to the moderate attacks, LC was superior than placebo after 1, 2 and 4 hours. The consumption of other rescue medications after 4 hours was significantly higher in the placebo group. With regard to the severe attacks, there was no difference between the active drug group and the placebo group concerning headache intensity and consumption of other rescue medications. We conclude that the NSAID lysine clonixinate is effective in treating moderately severe migraine attacks. It is not superior than placebo in treating severe migraine attacks.
几种口服非甾体抗炎药（NSAIDs）对治疗偏头痛发作有效。氯尼辛赖氨酸（LC）是一种源自烟酸的非甾体抗炎药，已被证明对各种疼痛综合征有效，如肾绞痛和肌肉疼痛。这项双盲、安慰剂对照研究的目的是评估口服LC与安慰剂相比在偏头痛急性治疗中的疗效。根据国际头痛协会（IHS）标准，对64例偏头痛诊断患者进行前瞻性研究。一旦头痛达到中度或重度强度，患者连续6次发作时接受LC或安慰剂治疗。对于中度发作，在1小时、2小时和4小时后，LC优于安慰剂。4小时后，安慰剂组其他急救药物的使用量明显更高。对于重度发作，活性药物组和安慰剂组在头痛强度和其他急救药物的使用方面没有差异。我们得出结论，非甾体抗炎药氯尼辛赖氨酸在治疗中度至重度偏头痛发作方面有效。在治疗重度偏头痛发作方面，它并不优于安慰剂。
