一种来自朱唇鼠尾草的具有解痉活性的新二萜类化合物。
A new diterpenoid with antispasmodic activity from Salvia cinnabarina.
作者信息
Romussi G, Ciarallo G, Bisio A, Fontana N, De Simone F, De Tommasi N, Mascolo N, Pinto L
机构信息
Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Genova, Italy.
出版信息
Planta Med. 2001 Mar;67(2):153-5. doi: 10.1055/s-2001-11511.
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.
从朱唇地上部分的叶表面渗出物中获得了一种新的半日花烷二萜类化合物，它对组胺、乙酰胆碱和氯化钡诱导的豚鼠离体回肠收缩具有非特异性解痉活性。所获得的IC50值与罂粟碱的IC50值相当。通过一维和二维核磁共振光谱技术确定了3,4-裂环异海松-4(18),7,15-三烯-3-酸的结构。
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