Labrid C, Dureng G, Bert H
C R Seances Soc Biol Fil. 1977;171(4):764-70.
The interaction of papaverine and tiemonium alone or combined, with BaCL2 and histamine on guinea pig ileum and with acetylcholine on rat jejunum have been studied with the help of molecular pharmacology techniques. The competitive antagonist effects of tiemonium and the non competitive antagonist effects of papaverine are evidenced and shown to be strictly additive when the two drugs are combined. This reflects a sequential blockage of the effects of acetylcholine, histamine and barium ions at the smooth muscle level. No such antagonism has been previously described in the case of the interaction with barium chloride with any other combination of two spasmolytic drugs.
借助分子药理学技术，研究了罂粟碱和替莫铵单独使用或联合使用时，与氯化钡、组胺对豚鼠回肠的相互作用，以及与乙酰胆碱对大鼠空肠的相互作用。证实了替莫铵的竞争性拮抗作用和罂粟碱的非竞争性拮抗作用，并且当两种药物联合使用时，这些作用严格相加。这反映了乙酰胆碱、组胺和钡离子在平滑肌水平上的效应被依次阻断。在与氯化钡相互作用的情况下，此前尚未有其他两种解痉药物组合呈现出这种拮抗作用的描述。
