长蒌叶胡椒中的二氢查耳酮

Dihydrochalcones from Piper longicaudatum.

作者信息

Joshi A S, Li X C, Nimrod A C, elSohly H N, Walker L A, Clark A M

出版信息

Planta Med. 2001 Mar;67(2):186-8. doi: 10.1055/s-2001-11517.

DOI:10.1055/s-2001-11517

Abstract

Bioactivity-guided fractionation of an ethanolic extract of the leaves and twigs of Piper longicaudatum Trelease & Yunker (Piperaceae) resulted in the isolation of one new (1) and three known (2-4) dihydrochalcones. The known compounds are: 2',6'-dihydroxy-4'-methoxydihydrochalcone (2), 2',6',4-trihydroxy-4'-methoxydihydrochalcone (asebogenin) (3), and 2'-hydroxy-4'-methoxy-2'-[1-hydroxy-1-methylethyl]-2",3"-dihy- drofurano[4",5":5',6"]-3"-[2-hydroxy-5-methoxycarbonylphe- nyl]dihydrochalcone (piperaduncin B) (4). The new compound is 2'-hydroxy-4'-methoxy-2"-[2-hydroxy-5-methoxycarbonyl- phenyl]-furano[4",5":5',6']-dihydrochalcone (longicaudatin) (1). Compounds 1-4 were tested for antibacterial activity against S. aureus and methicillin-resistant S. aureus (MRSA); only compound 3 showed inhibitory activity (IC50 of 10 and 4.5 micrograms/ml, respectively).

摘要

对长柄胡椒（胡椒科）叶和嫩枝乙醇提取物进行生物活性导向分离，得到了一种新的二氢查耳酮（1）和三种已知的二氢查耳酮（2 - 4）。已知化合物为：2',6'-二羟基-4'-甲氧基二氢查耳酮（2）、2',6',4-三羟基-4'-甲氧基二氢查耳酮（毒八角素）（3）和2'-羟基-4'-甲氧基-2'-[1-羟基-1-甲基乙基]-2",3"-二氢呋喃并[4",5":5',6"]-3"-[2-羟基-5-甲氧基羰基苯基]二氢查耳酮（胡椒邓辛B）（4）。新化合物为2'-羟基-4'-甲氧基-2"-[2-羟基-5-甲氧基羰基苯基]-呋喃并[4",5":5',6']-二氢查耳酮（长柄胡椒素）（1）。对化合物1 - 4进行了针对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性测试；只有化合物3显示出抑制活性（IC50分别为10和4.5微克/毫升）。