Li M, Chen X, Tang Q M, Zhang J S
Planta Med. 2001 Mar;67(2):189-90. doi: 10.1055/s-2001-11518.
Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberberine (1) and 2,3,9,10-dimethylenedioxy-1,8-dihydroxyprotoberberine (2), together with nine known isoquinoline-type alkaloids were isolated from the roots of Thalictrum delavayi. Their structures were elucidated by spectral methods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D1) in vitro. The competitive inhibitions were 87.5% (10(-4) M) and 15.6% (10(-6) M), respectively.
从云南铁线莲的根中分离得到两个新的原小檗碱生物碱，2,3,9,10-亚甲二氧基-8-氧代原小檗碱（1）和2,3,9,10-亚甲二氧基-1,8-二羟基原小檗碱（2），以及9个已知的异喹啉类生物碱。通过光谱方法阐明了它们的结构。在这些化合物中，伪原托品碱在体外多巴胺受体结合试验（D1）中表现出竞争性抑制活性。竞争性抑制率分别为87.5%（10⁻⁴ M）和15.6%（10⁻⁶ M）。
