蝙蝠葛中的异喹啉和异吲哚生物碱。

Isoquinoline and isoindole alkaloids from Menispermum dauricum.

作者信息

Zhang Xiaoqi, Ye Wencai, Zhao Shouxun, Che Chun-Tao

机构信息

Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Phytochemistry. 2004 Apr;65(7):929-32. doi: 10.1016/j.phytochem.2003.12.004.

DOI:10.1016/j.phytochem.2003.12.004

PMID:15081297

Abstract

Three isoquinoline alkaloids and an isoindole alkaloid, along with eight known compounds, were isolated from the roots of Menispermum dauricum (Menispermacese). The alkaloids were characterized as 7-hydroxy-6-methoxy-1(2H)-isoquinolinone, 6,7-dimethoxy-N-methyl-3,4-dioxo-1(2H)-isoquinolinone, 1-(4-hydroxybenzoyl)-7-hydroxy-6-methoxy-isoquinoline and 6-hydroxy-5-methoxy-N-methylphthalimide, on the basis of spectral evidence including 1D- and 2D-NMR and MS analyses.

摘要

从蝙蝠葛（防己科）的根中分离出三种异喹啉生物碱、一种异吲哚生物碱以及八种已知化合物。基于包括一维和二维核磁共振及质谱分析在内的光谱证据，这些生物碱被鉴定为7-羟基-6-甲氧基-1（2H）-异喹啉酮、6,7-二甲氧基-N-甲基-3,4-二氧代-1（2H）-异喹啉酮、1-（4-羟基苯甲酰基）-7-羟基-6-甲氧基异喹啉以及6-羟基-5-甲氧基-N-甲基邻苯二甲酰亚胺。