Golier J A, Yehuda R, Schmeidler J, Siever L J
Department of Psychiatry, Mount Sinai School of Medicine, Bronx VA Medical Center, 00MH, 130 West Kingsbridge Road, Bronx, NY 10468, USA.
Depress Anxiety. 2001;13(2):97-100. doi: 10.1002/da.1022.
In order to better characterize the similarities in and differences between the nature of the affective disturbance associated with Posttraumatic Stress Disorder (PTSD) and with Major Depressive Disorder (MDD), self-reported mood and anxiety ratings were examined in PTSD subjects, MDD subjects, and subjects without a psychiatric disorder while they were undergoing a chronobiologic study. Based on serial ratings on visual analogue scales over a 24 hr period, PTSD subjects showed comparable levels of depression as the MDD group, as measured by the mean and maximum levels of mood; however, they had greater mood variability, as measured by the range and coefficients of variation of the mood ratings. The MDD but not the PTSD group had significantly lower mood variability than the non-psychiatric group, as measured by the coefficients of variation. The PTSD group reported higher levels of anxiety than the non-psychiatric or MDD group but showed no differences in any measure of variability of anxiety. These findings suggest there are phenomenologic differences in the affective symptoms experienced by patients with PTSD and with MDD and that mood variability may distinguish between them.
为了更好地描述创伤后应激障碍（PTSD）和重度抑郁症（MDD）相关情感障碍本质上的异同，在进行一项时间生物学研究时，对PTSD患者、MDD患者和无精神疾病的受试者的自我报告情绪和焦虑评分进行了检查。基于24小时内视觉模拟量表的系列评分，通过情绪的平均水平和最高水平测量，PTSD患者的抑郁水平与MDD组相当；然而，通过情绪评分的范围和变异系数测量，他们的情绪变异性更大。通过变异系数测量，MDD组而非PTSD组的情绪变异性显著低于非精神疾病组。PTSD组报告的焦虑水平高于非精神疾病组或MDD组，但在焦虑变异性的任何测量指标上均无差异。这些发现表明，PTSD患者和MDD患者经历的情感症状存在现象学差异，情绪变异性可能是区分二者的依据。
