Case Western Reserve University, Department of Psychological Sciences, 10900 Euclid Ave., Cleveland, OH 44106, USA.
J Anxiety Disord. 2011 Dec;25(8):1123-30. doi: 10.1016/j.janxdis.2011.08.003. Epub 2011 Aug 10.
How to best understand theoretically the nature of the relationship between co-occurring PTSD and MDD (PTSD+MDD) is unclear. In a sample of 173 individuals with chronic PTSD, we examined whether the data were more consistent with current co-occurring MDD as a separate construct or as a marker of posttraumatic stress severity, and whether the relationship between PTSD and MDD is a function of shared symptom clusters and affect components. Results showed that the more severe depressive symptoms found in PTSD+MDD as compared to PTSD remained after controlling for PTSD symptom severity. Additionally, depressive symptom severity significantly predicted co-occurring MDD even when controlling for PTSD severity. In comparison to PTSD, PTSD+MDD had elevated dysphoria and re-experiencing - but not avoidance and hyperarousal - PTSD symptom cluster scores, higher levels of negative affect, and lower levels of positive affect. These findings provide support for PTSD and MDD as two distinct constructs with overlapping distress components.
如何从理论上最好地理解共病 PTSD 和 MDD（PTSD+MDD）之间的关系尚不清楚。在一项 173 名慢性 PTSD 个体的样本中，我们研究了数据是否更符合当前共病 MDD 作为一个独立的结构，还是作为创伤后应激严重程度的标志，以及 PTSD 和 MDD 之间的关系是否是共享症状群和情感成分的函数。结果表明，与 PTSD 相比，PTSD+MDD 中发现的更严重的抑郁症状在控制 PTSD 症状严重程度后仍然存在。此外，即使在控制 PTSD 严重程度后，抑郁症状严重程度也显著预测了共病 MDD。与 PTSD 相比，PTSD+MDD 的心境恶劣和再体验得分升高，但回避和过度警觉得分没有升高，负性情绪水平升高，正性情绪水平降低。这些发现为 PTSD 和 MDD 作为两个具有重叠痛苦成分的不同结构提供了支持。
