伊曲康唑口服溶液在中性粒细胞减少儿童长期预防期间的药代动力学
Pharmacokinetics of itraconazole oral solution in neutropenic children during long-term prophylaxis.
作者信息
Schmitt C, Perel Y, Harousseau J L, Lemerle S, Chwetzoff E, le Moing J P, Levron J C
机构信息
Hôpital d'Enfants, Vandoeuvre les Nancy, France.
出版信息
Antimicrob Agents Chemother. 2001 May;45(5):1561-4. doi: 10.1128/AAC.45.5.1561-1564.2001.
Abstract
We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two groups of neutropenic children stratified by age. Effective concentrations of itraconazole in plasma were reached quickly and maintained throughout treatment. The results indicate a trend toward higher concentrations of itraconazole in plasma in older children.
摘要
我们在两组按年龄分层的中性粒细胞减少儿童中研究了伊曲康唑口服溶液的药代动力学和安全性。伊曲康唑在血浆中的有效浓度迅速达到并在整个治疗过程中维持。结果表明年龄较大儿童血浆中伊曲康唑浓度有升高趋势。
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