Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Antiviral Res. 2018 Jan;149:75-77. doi: 10.1016/j.antiviral.2017.11.011. Epub 2017 Nov 15.
Parechovirus A3 (Par-A3, formerly human parechovirus 3) is an emerging viral infection of the central nervous system in children. We used an automated, homogeneous, cell based assay to identify itraconazole and posaconazole as inhibitors of Par-A3, with antiviral activity below concentrations clinically attainable in pediatric patients. Currently, there is no approved antiviral treatment for Par-A3 infection, despite numerous reports of serious Par-A3 disease in neonates and infants.
肠道病毒 A3(Par-A3,原称人类肠道病毒 3)是一种儿童中枢神经系统的新兴病毒感染。我们使用自动化、均相、基于细胞的检测方法,发现伊曲康唑和泊沙康唑是肠道病毒 A3 的抑制剂,其抗病毒活性低于儿科患者临床可达到的浓度。尽管有许多关于新生儿和婴儿严重肠道病毒 A3 疾病的报告,但目前尚无针对肠道病毒 A3 感染的批准抗病毒治疗方法。