颈部同时发生霍奇金淋巴瘤的Castleman病浆细胞变异型。

Plasma cell variant of Castleman's disease occurring concurrently with Hodgkin's disease in the neck.

作者信息

Frank D K, Charney D, Kashani A

机构信息

The Max L. Som Department of Otolaryngology-Head and Neck Surgery and the Institute for Head and Neck Cancer, Beth Israel Medical Center, New York, New York 10003, USA.

出版信息

Head Neck. 2001 Feb;23(2):166-9. doi: 10.1002/1097-0347(200102)23:2<166::aid-hed1012>3.0.co;2-p.

DOI:10.1002/1097-0347(200102)23:2<166::aid-hed1012>3.0.co;2-p

PMID:11303634

Abstract

BACKGROUND

Castleman's disease, a benign lymphoproliferative disorder, may be seen as a self-limited, curable unifocal process, or highly aggressive multicentric disease frequently resulting in death despite aggressive management. Non-Hodgkin's lymphoma has been known to arise within the context of Castleman's disease, usually when multicentric. Hodgkin's lymphoma, however, can also arise within the context of Castleman's disease, but this is a rare process. We report a case of unifocal Castleman's disease (plasma cell variant) occurring concurrently with Hodgkin's disease in the neck of a young woman.

METHODS

The presentation, workup, pathologic evaluation, and management of a young woman diagnosed with Castleman's disease occurring concurrently with Hodgkin's disease in the neck is presented and discussed.

RESULTS

A 32-year-old woman with a 5-year history of unifocal right cervicoparotid Castleman's disease (plasma cell variant) underwent right functional neck dissection and superficial parotidectomy for cosmetic and functional purposes. Pathologic and immunohistochemical analysis confirmed Hodgkin's lymphoma occurring in a background of the plasma cell variant of Castleman's disease. The patient subsequently underwent external beam radiation therapy as definitive management for her early-stage Hodgkin's lymphoma.

CONCLUSIONS

Castleman's disease can occur as an isolated regional process in the head and neck. Furthermore, lymphoma (and specifically Hodgkin's lymphoma) can develop within regionally isolated cervical Castleman's disease. Although complete surgical excision of unifocal Castleman's disease is curative, the management of lymphoma occurring within the context of the Castleman's disease warrants a standard lymphoma workup and management strategy.

摘要

背景

Castleman病是一种良性淋巴增生性疾病，可表现为自限性、可治愈的单灶性病变，或高度侵袭性的多中心性疾病，尽管积极治疗仍常导致死亡。已知非霍奇金淋巴瘤可在Castleman病的背景下发生，通常是在多中心性Castleman病时。然而，霍奇金淋巴瘤也可在Castleman病的背景下出现，但这是一个罕见的情况。我们报告一例年轻女性颈部单灶性Castleman病（浆细胞型）与霍奇金病同时发生的病例。