Maheswaran P R, Ramsay A D, Norton A J, Roche W R
Department of Pathology, University of Southampton, UK.
Histopathology. 1991 Mar;18(3):249-53. doi: 10.1111/j.1365-2559.1991.tb00833.x.
Three cases are reported in which an initial diagnosis of the plasma cell variant of Castleman's disease was made, but in which a second lymph node biopsy within a year showed evidence of Hodgkin's disease. Review of the initial biopsy indicated that atypical CD15 and CD30 positive cells were present in the initial biopsy. This illustrates the difficulty in making the diagnosis of Castleman's disease and suggests that the lymphoid reaction to the presence of Hodgkin's disease may result in similar histological appearances. The need for re-evaluation of the diagnosis of Castleman's disease in the face of persistent or recurrent disease is stressed.
报告了3例病例，最初诊断为Castleman病的浆细胞变异型，但在一年内进行的第二次淋巴结活检显示有霍奇金病的证据。对最初活检的复查表明，最初的活检中存在非典型CD15和CD30阳性细胞。这说明了诊断Castleman病的困难，并提示对霍奇金病存在的淋巴样反应可能导致相似的组织学表现。强调了在面对持续性或复发性疾病时对Castleman病诊断进行重新评估的必要性。
