Fuentes S, Bouillot P, Regis J, Lena G, Choux M
Department of Pediatric Neurosurgery, La Timone, Marseille, France.
Br J Neurosurg. 2001 Feb;15(1):57-62. doi: 10.1080/026886901300004120.
The brain stem is an uncommon site of a brain abscess. Such lesions were invariably fatal before 1974, when the arrival of computed tomography and magnetic resonance imaging improved the prognosis. This new case with a good result shows the usefulness of early diagnosis, careful clinical and radiological monitoring and combined medical and surgical management. A child 2 1/2 years of age was admitted to the department of neurosurgery for diagnosis and treatment of a brain stem lesion. The clinical context and discovery of an intrabronchial foreign body, as well as neuroradiological investigations, suggested a diagnosis of brain stem abscess. Initial treatment with broad spectrum antibiotics with good cerebral penetration was associated with an increase in the size of the abscess and clinical worsening. Stereotactic aspiration of lesion was performed by a transpeduncular approach under CT guidance and general anaesthesia. Secondary thoracotomy enabled removal of an intrabronchial needle. After evacuation, in spite of failure to identify the organism, neurological deficit resolved rapidly and the lesion no longer appeared on CT. Management of a brain abscess always includes antibiotics. They must cover the organisms most often encountered in brain abscesses and have good cerebral penetration. Medical treatment seems to suffice for small abscesses. A brain stem abscess with rapid clinical signs, together with current neuroradiogical diagnostic techniques, enables early discovery of such abscesses when they are still small. Treatment of brain stem abscesses includes primary antibiotic therapy, then stereotaxic drainage when there is any diagnostic doubt, poor clinical tolerability or antibiotic resistance.
脑干是脑脓肿的罕见发病部位。在1974年计算机断层扫描和磁共振成像出现改善预后之前,此类病变总是致命的。这个预后良好的新病例显示了早期诊断、仔细的临床和放射学监测以及药物与手术联合治疗的有效性。一名2岁半的儿童因脑干病变被收入神经外科进行诊断和治疗。临床情况、支气管内异物的发现以及神经放射学检查提示为脑干脓肿。最初使用具有良好脑穿透性的广谱抗生素治疗,结果脓肿大小增加且临床症状恶化。在CT引导和全身麻醉下,通过经脚间池入路对病变进行立体定向抽吸。二次开胸手术取出了支气管内的针头。抽出脓液后,尽管未能鉴定出病原体,但神经功能缺损迅速消失,CT上病变也不再显示。脑脓肿的治疗始终包括使用抗生素。抗生素必须覆盖脑脓肿中最常遇到的病原体,并且具有良好的脑穿透性。对于小脓肿,药物治疗似乎就足够了。脑干脓肿伴有快速的临床症状,结合当前的神经放射学诊断技术,能够在脓肿尚小时早期发现此类脓肿。脑干脓肿的治疗包括初始抗生素治疗,然后在存在诊断疑问、临床耐受性差或抗生素耐药时进行立体定向引流。