Kusaka T, Isobe K, Nagano K, Okubo K, Yasuda S, Kondo M, Itoh S, Onishi S
Department of Pediatrics, Kagawa Medical University, Mikicho 1750-1, Kitagun, Kagawa, 761-0793, Japan.
Neuroimage. 2001 May;13(5):944-52. doi: 10.1006/nimg.2001.0755.
Near-infrared topography with indocyanine green was used to measure regional cerebral blood flow (rCBF) in the temporal lobes of infants. The mean rCBF in infants without neural abnormality was 14.5 +/- 3.1 ml/100 g/min, and the rCBFs in the fronto-temporal, temporal, and occipito-temporal regions were 15.1 +/- 3.9, 15.4 +/- 3.3, and 14.6 +/- 3.3 ml/100 g/min, respectively. Moreover, in one asphyxiated infant with infarction and one infant with subdural and intracerebellar hemorrhage, it was demonstrated that the area of defective blood flow could be detected as well as it can by SPECT. This technique makes it possible to estimate rCBF distribution in infants at the bedside. Thus, in the future, evaluation of various neonatal illnesses should be feasible.
采用吲哚菁绿近红外地形图测量婴儿颞叶的局部脑血流量（rCBF）。无神经异常的婴儿平均rCBF为14.5±3.1 ml/100 g/min，额颞、颞叶和枕颞区域的rCBF分别为15.1±3.9、15.4±3.3和14.6±3.3 ml/100 g/min。此外，在一名患有梗死的窒息婴儿和一名患有硬膜下及小脑内出血的婴儿中，结果表明该技术与单光子发射计算机断层扫描（SPECT）一样能够检测到血流缺陷区域。这项技术使得在床边估计婴儿的rCBF分布成为可能。因此，未来对各种新生儿疾病的评估应该是可行的。
