Toet Mona C, Lemmers Petra M A
Department of Neonatology, Wilhelmina Children's Hospital UMC, Utrecht, The Netherlands.
Early Hum Dev. 2009 Feb;85(2):77-84. doi: 10.1016/j.earlhumdev.2008.11.007. Epub 2009 Jan 17.
Continuous EEG monitoring with amplitude-integrated electroencephalography (aEEG) has become a part of the routine neurological care in the neonatal unit, especially in full-term infants with hypoxia-ischemia and in infants suspected of seizures. Its prognostic value after birth asphyxia is well established and seizure detection has improved with the new digital aEEG devices with access to the "real" EEG, and even with seizure detection in some devices. Recent experience shows that aEEG monitoring also appears to be very helpful in premature infants. One has to be aware of possible artefacts, like ECG or movement artefacts, which can lead to misinterpretation of the background pattern. Cerebral oximetry records regional saturation of the brain using Near Infrared Spectroscopy (NIRS) and provides a non-invasive method to continuously monitor brain oxygen imbalance. Cerebral oximetry is increasingly being used as a trend monitor in critically ill neonates. Its usefulness has been assessed in cardiac surgery, patent ductus arteriosus, hypoxia-ischemia and ventilation with high mean airway pressures. A combination of both monitoring modalities will probably become the future for neonatal neuromonitoring.
采用振幅整合脑电图(aEEG)进行连续脑电图监测已成为新生儿病房常规神经护理的一部分,尤其是对于患有缺氧缺血性脑病的足月儿以及疑似癫痫发作的婴儿。其在出生窒息后的预后价值已得到充分证实,随着新型数字aEEG设备能够获取“真实”脑电图,甚至在某些设备中能够检测到癫痫发作,癫痫检测也得到了改善。最近的经验表明,aEEG监测在早产儿中似乎也非常有帮助。必须注意可能出现的伪迹,如心电图或运动伪迹,它们可能导致对背景模式的错误解读。脑氧饱和度测定法使用近红外光谱(NIRS)记录大脑局部饱和度,并提供一种连续监测脑氧失衡的非侵入性方法。脑氧饱和度测定法越来越多地被用作危重新生儿的趋势监测指标。其在心脏手术、动脉导管未闭、缺氧缺血以及高平均气道压通气中的作用已得到评估。这两种监测方式的结合可能会成为新生儿神经监测的未来发展方向。