Orisakwe O E, Ilondu N D, Afonne O J, Ofoefule S I, Orish C N, Agbasi P U
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria.
Am J Ther. 2001 Jan-Feb;8(1):7-9. doi: 10.1097/00045391-200101000-00003.
We investigated the effect of the oral binder-activated charcoal on the excretion of diethylcarbamazine. Six healthy volunteers were given 150 mg diethylcarbamazine with 350 mL water each. One and 2 weeks later, they received 150 mg diethylcarbamazine plus 7.5 and 15 g activated charcoal, respectively, in 350 mL water as a charcoal slurry. Urinary levels of diethylcarbamazine were measured spectrophotometrically from 1 to 72 hours after ingestion in three different periods. Treatment with activated charcoal led to 5.4% urinary recovery of diethylcarbamazine, decreased excretion rate, and a much lower plateau indicator of reduced absorption. Activated charcoal reduces the absorption and urinary excretion rate of diethylcarbamazine by adsorbing it in the gastrointestinal tract.
我们研究了口服吸附剂活性炭对乙胺嗪排泄的影响。六名健康志愿者每人服用150毫克乙胺嗪并饮用350毫升水。1周和2周后，他们分别服用150毫克乙胺嗪加7.5克和15克活性炭，制成活性炭混悬液并与350毫升水一起服用。在三个不同时间段内，于摄入后1至72小时用分光光度法测定尿中乙胺嗪水平。活性炭治疗使乙胺嗪的尿回收率达到5.4%，排泄率降低，且吸收减少的平台指标低得多。活性炭通过在胃肠道中吸附乙胺嗪来降低其吸收和尿排泄率。
