动物成熟度对前列腺素E2和F2α的平滑肌及血压反应的影响。

Effects of animal maturity on smooth muscle and blood pressure responses to prostaglandins E2 and F2alpha.

作者信息

Okpako D T

出版信息

J Pharm Pharmacol. 1976 Aug;28(8):613-6. doi: 10.1111/j.2042-7158.1976.tb02811.x.

DOI:10.1111/j.2042-7158.1976.tb02811.x

Abstract

The effects of prostaglandins E2 (PGE2) and F2alpha (PGF2-alpha) on muscle strips from mature and immature rats and guinea-pigs and on rat blood pressure were investigated in the presence of atropine. The colon and stomach strips from immature rats were equally responsive to PGE 2 and PGF2alpha where mature colons were significantly more sensitive to PGF2ALPHA AND MATURE STOMACH STRIPS SIGNIFICANTLY MORE SENSITIVE TO PGE2. On the ileum from immature guinea-pigs the maximum responses to PGE2 and PGF2alpha were 16 and 8% of the histamine maximum respectively. The corresponding figures on the mature ileum were 86 and 75%. Whereas PGE2 was only twice as active as PGF2alpha on immature ilea, it was ten times more active than PGF2alpha on mature muscles. On blood pressure PGF2alpha and PGE2 were both hypotensive in immature rats whereas PGE2 was hypotensive and PGF2alpha hypertensive in mature rats. The results suggest that as the animal gets older, receptors for prostaglandins became increasingly differentiated.

摘要

在阿托品存在的情况下，研究了前列腺素E2（PGE2）和F2α（PGF2-α）对成熟和未成熟大鼠及豚鼠的肌肉条以及对大鼠血压的影响。未成熟大鼠的结肠和胃条对PGE2和PGF2α的反应相同，而成熟结肠对PGF2α的敏感性显著更高，成熟胃条对PGE2的敏感性显著更高。在未成熟豚鼠的回肠上，对PGE2和PGF2α的最大反应分别为组胺最大反应的16%和8%。成熟回肠上的相应数字分别为86%和75%。在未成熟回肠上，PGE2的活性仅为PGF2α的两倍，而在成熟肌肉上，其活性比PGF2α高十倍。在血压方面，PGF2α和PGE2在未成熟大鼠中均引起低血压，而在成熟大鼠中，PGE2引起低血压，PGF2α引起高血压。结果表明，随着动物年龄的增长，前列腺素受体变得越来越分化。