前列腺素E2及其三种肺代谢物的比较生物测定
Comparative bioassay of prostaglandin E2 and its three pulmonary metabolites.
作者信息
Crutchley D J, Piper P J
出版信息
Br J Pharmacol. 1975 Jul;54(3):397-9. doi: 10.1111/j.1476-5381.1975.tb07581.x.
Abstract
The relative potencies of prostaglandin E2 and its metabolites 15-keto PGE2, 13,14-dihydro-15-keto-PGE2 and 13,14,dihydro-PGE2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea-pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15-keto PGE2 was equiactive or 1-1.8 times more potent than prostaglandin E2 in relaxing guinea-pig trachea but otherwise the three metabolites were less active than prostaglandin E2 on all preparations.
摘要
在离体平滑肌制剂上研究了前列腺素E2及其代谢产物15-酮基-PGE2、13,14-二氢-15-酮基-PGE2和13,14-二氢-PGE2的相对效价。这些制剂包括大鼠胃条、结肠和子宫、鸡直肠、豚鼠回肠、气管和肺动脉以及兔主动脉和肺动脉。在舒张豚鼠气管方面，15-酮基-PGE2与前列腺素E2等效或效力比其高1-1.8倍，但在所有其他制剂上，这三种代谢产物的活性均低于前列腺素E2。
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