Mann D L
Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd., Houston TX 77030, USA.
Heart Fail Rev. 2001 Mar;6(2):71-80. doi: 10.1023/a:1011449708842.
Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
最近的研究已经明确了生物活性分子如神经激素在心力衰竭疾病进展中的重要性。最近还发现，除了神经激素外，另一类被称为细胞因子的生物活性分子在心力衰竭时也会表达。本文将综述近期的临床和实验资料，这些资料表明肿瘤坏死因子（TNF），一种促炎细胞因子，可能通过该分子对心脏和循环系统产生的直接毒性作用，促进心力衰竭的疾病进展。
