Baumgarten G, Knuefermann P, Mann D L
Winters Center for Heart Failure Research, the Cardiology Section, Department of Medicine, Veterans Administration Medical Center, and Baylor College of Medicine, Houston, TX 77030, USA.
Trends Cardiovasc Med. 2000 Jul;10(5):216-23. doi: 10.1016/s1050-1738(00)00063-3.
Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material which suggest that the cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) may represent another class of biologically active molecules that are responsible for the development and progression of heart failure. In addition, we also review the early results from clinical trials that have utilized various targeted anti-cytokine strategies in patients with heart failure.
最近的研究已经确定了生物活性分子如神经激素在心力衰竭疾病进展中的重要性。最近还发现，除了神经激素之外，另一类被称为细胞因子的生物活性分子在心力衰竭情况下也有表达。本文综述了近期的临床和实验资料，这些资料表明，肿瘤坏死因子（TNF）、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）等细胞因子可能代表另一类导致心力衰竭发生和进展的生物活性分子。此外，我们还综述了在心力衰竭患者中采用各种靶向抗细胞因子策略的临床试验的早期结果。
