Shamir M H, Rochkind S, Sandbank J, Alon M
Koret School of Veterinary Medicine, Hebrew University of Jerusalem.
J Reconstr Microsurg. 2001 Feb;17(2):133-7; discussion 138. doi: 10.1055/s-2001-12702.
This double-blind randomized study evaluated the therapeutic effect of low-power laser irradiation (LPLI) on peripheral nerve regeneration, after complete transection and direct anastomosis of the rat sciatic nerve. After this procedure, 13 of 24 rats received postoperative LPLI, with a wavelength of 780 nm laser, applied transcutaneously, 30 min daily for 21 consecutive days, to corresponding segments of the spinal cord and to the injured sciatic nerve. Positive somatosensory evoked responses were found in 69.2 percent of the irradiated rats (p = 0.019), compared to 18.2 percent of the non-irradiated rats. Immunohistochemical staining in the laser-treated group showed an increased total number of axons (p = 0.026), and better quality of the regeneration process, due to an increased number of large-diameter axons (p = 0.021), compared to the non-irradiated control group. The study suggests that postoperative LPLI enhances the regenerative processes of peripheral nerves after complete transection and anastomosis.
这项双盲随机研究评估了低功率激光照射（LPLI）对大鼠坐骨神经完全横断并直接吻合后周围神经再生的治疗效果。在此手术后，24只大鼠中有13只接受了术后LPLI，使用波长为780 nm的激光经皮照射，每天30分钟，连续21天，照射脊髓相应节段和受伤的坐骨神经。与未照射大鼠的18.2%相比，照射大鼠中有69.2%出现了阳性体感诱发电位反应（p = 0.019）。与未照射的对照组相比，激光治疗组的免疫组织化学染色显示轴突总数增加（p = 0.026），并且由于大直径轴突数量增加，再生过程质量更好（p = 0.021）。该研究表明，术后LPLI可增强周围神经在完全横断和吻合后的再生过程。
