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[裸鼠(nu/nu)人尸体皮肤移植的宏观与微观研究]

[Macroscopic and microscopic study of human corpse skin grafting on athymic mice nu/nu].

作者信息

Duprez A

出版信息

C R Seances Acad Sci D. 1979 May 21;288(19):1505-8.

PMID:113125
Abstract

32 thin grafts (500 to 700 mu) of different human corpse skin set apart during the first 24 hrs after the death have retaken on athymic Mousse whatever the reason of death and the age of the donor. 20 thick grafts have retaken at 30%. These skins preserve the aspects and behaviour of normal human skin but after 1 month they have a heavy melanic hyperpigmentation. These skins preserve their normal histological aspect during the first 3 days, then, when revascularisation is setting in, superficial areas of epidermic mortification, opposite dermal hypovascularised zones, appear. Between the 15th and the 21st day the epidermic alterations disappear and a heavy melanic hyperpigmentation is set up. The revascularisation is certainly the result of the human dermal vessels repermeabilisation. Till the 76th day neither dystrophy, dysplasia nor important inflammatory process exist.

摘要

32 片厚度为 500 至 700 微米的不同人尸体皮肤移植物,取自死亡后最初 24 小时内的尸体,无论死亡原因和供体年龄如何,均已在无胸腺小鼠身上重新生长。20 片厚移植物的成活率为 30%。这些皮肤保留了正常人类皮肤的外观和特性,但 1 个月后会出现严重的黑色素沉着过度。这些皮肤在最初 3 天保持正常的组织学外观,然后,当血管再生开始时,在真皮血管化不足区域相对应的表皮坏死浅表区域出现。在第 15 天至第 21 天之间,表皮改变消失,出现严重的黑色素沉着过度。血管再生肯定是人类真皮血管再通的结果。直到第 76 天,既没有营养不良、发育异常,也没有重要的炎症过程。

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