Garcia-Toro M, Mayol A, Arnillas H, Capllonch I, Ibarra O, Crespí M, Micó J, Lafau O, Lafuente L
Complejo Hospitalario GESMA, C/Jesús 40, 07003 Palma de Mallorca, Mallorca, Spain.
J Affect Disord. 2001 May;64(2-3):271-5. doi: 10.1016/s0165-0327(00)00223-8.
Controverted results have been obtained using high frequency transcranial magnetic stimulation (HF-rTMS) as an antidepressant treatment.
Forty patients suffering from drug-resistant major depression received ten sessions of HF-rTMS at 90% of the motor threshold on the left prefrontal cortex or sham stimulation, added to their pharmacological treatment, in a randomized double-blind design. In a second open phase, patients still fulfilling criteria of inclusion received ten additional sessions of HF-rTMS at 90 or 110%.
Real, but not sham HF-rTMS, was associated with a significant decrease in the Hamilton Depression Rating Scale, but only twelve patients decreased more than 50%.
Left prefrontal HF-rTMS was effectively associated with antidepressant treatment, although the size effect was small.
Shortage of the sample and control difficulties of the placebo effect.
Questionable in more than half of the patients studied.
使用高频重复经颅磁刺激（HF-rTMS）作为抗抑郁治疗已获得有争议的结果。
40名患有难治性重度抑郁症的患者，在随机双盲设计中，除接受药物治疗外，还在左侧前额叶皮质以运动阈值的90%接受十次HF-rTMS治疗或假刺激。在第二个开放阶段，仍符合纳入标准的患者以90%或110%的强度额外接受十次HF-rTMS治疗。
真正的HF-rTMS（而非假刺激）与汉密尔顿抑郁量表评分显著降低相关，但只有12名患者降低超过50%。
左侧前额叶HF-rTMS与抗抑郁治疗有效相关，尽管效应量较小。
样本量不足以及安慰剂效应的对照困难。
在所研究的超过一半的患者中存在疑问。
