Chandrasekhar S S
Division of Otolaryngology-HNS, UMDNJ-New Jersey Medical School and University Hospital, Newark, USA.
Otol Neurotol. 2001 Jan;22(1):18-23. doi: 10.1097/00129492-200101000-00005.
To discuss the value of intratympanic dexamethasone (IT-DEX) perfusion for sudden sensorineural hearing loss (SSNHL), clinically and in an animal model.
Retrospective case review of 10 patients with SSNHL treated with IT-DEX. The findings are correlated with this institution's previous findings from a study of IT-DEX in guinea pigs.
Ambulatory tertiary otologic referral center.
Sequential patients with SSNHL who chose IT-DEX treatment.
Dexamethasone 0.5 mg was injected transtympanically and bathed the round window for 20 minutes. Animal study: 79 ears were randomized into five groups: control, IT-DEX versus intravenous (IV)-DEX, IT-DEX with histamine, IT-DEX with hyaluronic acid, and IT-DEX with dimethylsulfoxide.
Clinical study: postprocedure audiometry. Animal study: perilymph steroid concentration.
IT-DEX results in significant hearing improvement and in significantly higher perilymph concentration of steroid than IV-DEX.
IT-DEX is an appropriate treatment option for the treatment of SSNHL. Further study of dosages and frequency of administration is warranted.
探讨鼓室内注射地塞米松（IT-DEX）灌注治疗突发性感音神经性听力损失（SSNHL）在临床及动物模型中的价值。
对10例接受IT-DEX治疗的SSNHL患者进行回顾性病例分析。研究结果与本机构先前对豚鼠进行的IT-DEX研究结果相关。
门诊三级耳科转诊中心。
选择IT-DEX治疗的连续性SSNHL患者。
经鼓膜注射0.5mg地塞米松，使其浸泡圆窗20分钟。动物研究：将79只耳朵随机分为五组：对照组、IT-DEX组与静脉注射（IV）-DEX组、IT-DEX联合组胺组、IT-DEX联合透明质酸组以及IT-DEX联合二甲亚砜组。
临床研究：术后听力测定。动物研究：外淋巴液中类固醇浓度。
与IV-DEX相比，IT-DEX能显著改善听力，且外淋巴液中类固醇浓度显著更高。
IT-DEX是治疗SSNHL的一种合适治疗选择。有必要进一步研究给药剂量和频率。
