Correia S D, David J M, David J P, Chai H B, Pezzuto J M, Cordell G A
College of Pharmacy, University of Illinois at Chicago, 60612, USA.
Phytochemistry. 2001 Apr;56(7):781-4. doi: 10.1016/s0031-9422(00)00476-3.
From the bark of Tapiria obtusa, six alkyl phenol derivatives were isolated: 1-hydroxy-3-[(Z)-7'-nonadecenyl]-benzene, 1-hydroxy-3-[(Z)-7'-heptadecenyl]-benzene, 1-hydroxy-3-[14'-phenyltetradecyl]-benzene, and 1-hydroxy-3-[16'-phenyltetradecyl]-benzene, and their possible biogenetic precursors, 1-(16'-phenyl-12'Z-hexadecenyl)-4-Z-cyclohexene-(1S*,3S*)-diol and (4S*,6S*)-dihydroxy-6-(14'Z-nonadecenyl)-2-cyclohexenone. The structures of these compounds were elucidated by chemical and spectroscopic analysis, (4S*,6S*)-Dihydroxy-6-(14'Z-nonadecenyl)-2-cyclohexenone showed cytotoxic activity.
1-羟基-3-[(Z)-7'-十九碳烯基]-苯、1-羟基-3-[(Z)-7'-十七碳烯基]-苯、1-羟基-3-[14'-苯基十四烷基]-苯和1-羟基-3-[16'-苯基十四烷基]-苯，以及它们可能的生物合成前体，1-(16'-苯基-12'Z-十六碳烯基)-4-Z-环己烯-(1S*,3S*)-二醇和(4S*,6S*)-二羟基-6-(14'Z-十九碳烯基)-2-环己烯酮。通过化学和光谱分析阐明了这些化合物的结构，(4S*,6S*)-二羟基-6-(14'Z-十九碳烯基)-2-环己烯酮显示出细胞毒性活性。
