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苦参黄酮B和H对莫氏槐（Sophora mooracroftiana Beth ex Baker）体外铜离子诱导的小鼠脑匀浆蛋白质氧化修饰的抑制作用

Inhibitory effects of sophoraflavanones B and H in Sophora mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate in vitro.

作者信息

Toda S, Shirataki Y

机构信息

Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Osaka, Japan.

出版信息

Biol Trace Elem Res. 2000 Winter;78(1-3):157-62. doi: 10.1385/BTER:78:1-3:157.

DOI:10.1385/BTER:78:1-3:157
PMID:11314975
Abstract

We present the results of an in vitro investigation of the inhibitory effects of sophoraflavanones B and H isolated from Sophora mooracroftiana Beth ex Baker on copper-induced protein oxidative modification. They inhibited copper-induced protein oxidative modification. Their effects were stronger than those of naringenin as a related flavanone, and of mannitol as a hydroxyl radical scavenger. The results suggest that these natural products may be of use in cases where oxidative stress is present.

摘要

我们展示了从西藏苦参（Sophora mooracroftiana Beth ex Baker）中分离得到的槐黄酮B和H对铜诱导的蛋白质氧化修饰抑制作用的体外研究结果。它们抑制了铜诱导的蛋白质氧化修饰。其效果强于作为相关黄酮类化合物的柚皮素以及作为羟基自由基清除剂的甘露醇。结果表明，这些天然产物可能对存在氧化应激的情况有用。

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