Toda S, Shirataki Y
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Osaka, Japan.
Biol Trace Elem Res. 2001 Aug;81(2):169-75. doi: 10.1385/BTER:81:2:169.
We present the results of an in vitro investigation of the inhibitory effects of licoisoflavones A and B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavones A and B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavones A and B were weaker than those of genistein and mannitol. These results demonstrated that the difference of inhibitory effects are dependent on the relation between chemical structures of these isoflavones, such as hydroxy group or benzopyran, and oxidative stress.
我们展示了从白花苦豆（BETH ex BAKER）中分离得到的光甘草定A、光甘草定B和槐属异黄酮A对小鼠脑匀浆铜诱导的蛋白质氧化修饰的体外抑制作用的体外研究结果。虽然槐属异黄酮A的抑制作用强于光甘草定A和光甘草定B，染料木黄酮作为相关异黄酮，甘露醇作为羟基自由基清除剂，但光甘草定A和光甘草定B的抑制作用弱于染料木黄酮和甘露醇。这些结果表明，抑制作用的差异取决于这些异黄酮的化学结构之间的关系，如羟基或苯并吡喃，以及氧化应激。
