Van Coeverden S C, De Ridder C M, Roos J C, Van't Hof M A, Netelenbos J C, Delemarre-Van de Waal H A
Department of Pediatrics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
J Bone Miner Res. 2001 Apr;16(4):774-81. doi: 10.1359/jbmr.2001.16.4.774.
To assess risks for osteoporosis and to compare bone mass in different groups of healthy children or children with diseases, it is important to have knowledge of their sexual maturation status during puberty. The aim of our study was to evaluate bone mass formation longitudinally in relation to pubertal maturation characteristics in healthy white girls. We investigated the bone mineral content (BMC) and the bone mineral density (BMD) at different skeletal sites in 151 girls with increasing pubertal stages in relation with their chronological age and with an early or late onset of puberty or menarche and with a slow or fast maturation. Bone mass was measured at the onset of puberty, during puberty, and at menarche. We conclude the following: (1) from midpuberty to menarche, the increase in bone mass formation is highest at all skeletal sites in white girls; (2) early mature girls at the onset of puberty have slightly but definitely lower bone masses at all skeletal sites and at all pubertal stages than late mature girls, whereas the average bone mass formation from the onset of puberty to menarche is similar in both groups; (3) girls with a slow rate of pubertal maturation have lower bone mass values 2 years after the onset of puberty, but at menarche bone mass is similar compared with fast maturers; and (4) it cannot be confirmed that there is an effect of menarcheal age on bone mass values at menarche.
为评估骨质疏松症风险并比较不同组健康儿童或患病儿童的骨量，了解他们青春期的性成熟状态很重要。我们研究的目的是纵向评估健康白人女孩骨量形成与青春期成熟特征的关系。我们调查了151名处于不同青春期阶段女孩不同骨骼部位的骨矿物质含量（BMC）和骨矿物质密度（BMD），这些女孩的青春期或月经初潮有早有晚，成熟速度有快有慢，同时考虑了她们的实际年龄。在青春期开始时、青春期期间和月经初潮时测量骨量。我们得出以下结论：（1）从青春期中期到月经初潮，白人女孩所有骨骼部位的骨量形成增加幅度最大；（2）青春期开始时早熟女孩在所有骨骼部位和所有青春期阶段的骨量均略低于晚熟女孩，但两组从青春期开始到月经初潮的平均骨量形成相似；（3）青春期成熟速度较慢的女孩在青春期开始2年后骨量值较低，但在月经初潮时骨量与早熟女孩相似；（4）无法证实月经初潮年龄对月经初潮时的骨量值有影响。
