Magarey A M, Boulton T J, Chatterton B E, Schultz C, Nordin B E, Cockington R A
Department of Public Health, Flinders University of South Australia, Adelaide, Australia.
Acta Paediatr. 1999 Feb;88(2):139-46. doi: 10.1080/08035259950170286.
The tempo and change in bone growth during puberty in relation to physical growth is described in a cohort of 56 boys and 52 girls. Distal forearm bone width, mineral content and volumetric density, anthropometry and pubertal status were measured at ages 11, 13, 15 and 17 y, and bone age at 17 y. Bone width and mineral content increased independently with age for each pubertal stage. Volumetric density fell during early puberty and then increased rapidly. Maximal increase of all bone variables occurred earlier in girls than in boys and earliest for bone width, then mineral content, then density. In girls most change occurred in the 12 mo before and after menarche. The degree of tracking was similar to that for height. Bone growth followed physical growth but at a slower tempo. By age 17 y boys had attained 86% of the reference adult bone mineral content and volumetric density; girls had attained 93% of the reference adult bone mineral content and 94% of volumetric density. Those skeletally mature at 17 y had greater mineral content and volumetric density. To maximize peak bone mass, modifiable environmental factors should be optimized before the onset of puberty and be maintained throughout this period of rapid growth and beyond attainment of sexual maturity.
在一个由56名男孩和52名女孩组成的队列中，描述了青春期骨骼生长的节奏和变化与身体生长的关系。在11岁、13岁、15岁和17岁时测量了远端前臂骨宽度、矿物质含量和体积密度、人体测量学指标和青春期状态，并在17岁时测量了骨龄。每个青春期阶段，骨宽度和矿物质含量均随年龄独立增加。体积密度在青春期早期下降，然后迅速上升。所有骨骼变量的最大增加在女孩中比在男孩中出现得更早，骨宽度最早，其次是矿物质含量，然后是密度。在女孩中，大多数变化发生在初潮前后12个月内。追踪程度与身高相似。骨骼生长遵循身体生长，但节奏较慢。到17岁时，男孩已达到参考成人骨矿物质含量和体积密度的86%；女孩已达到参考成人骨矿物质含量的93%和体积密度的94%。那些在17岁时骨骼成熟的人具有更高的矿物质含量和体积密度。为了使峰值骨量最大化，应在青春期开始前优化可改变的环境因素，并在这个快速生长时期以及性成熟之后一直保持。
