Brüssow H, Barclay D, Sidoti J, Rey S, Blondel A, Dirren H, Verwilghen A M, Van Geert C
Nestlé Research Center, Nestec Ltd., Lausanne, Switzerland.
Clin Diagn Lab Immunol. 1996 Jan;3(1):37-41. doi: 10.1128/cdli.3.1.37-41.1996.
Serum and human milk antimicrobial antibody titers were measured longitudinally in 17 malnourished and 14 control Zairian women during 6 to 18 months of lactation to test whether malnutrition is specifically associated with an impaired secretory antibody response. No decreases in total serum and human milk immunoglobulin concentrations, neutralizing antibody titers against rotavirus, or specific enzyme-linked immunosorbent assay antibody titers against rotavirus, respiratory syncytial virus, Escherichia coli, Streptococcus pneumoniae, and Haemophilus influenzae were detected when malnourished women were compared with control women. Malnutrition had no effect on circulating and secretory antibody concentrations in Zairian women. Daily human milk outputs, however, were about 30% lower in malnourished than in control women, resulting in a correspondingly lower ingestion of immunoglobulins by the children of malnourished women.
在17名营养不良的扎伊尔妇女和14名对照扎伊尔妇女的6至18个月哺乳期内，纵向测量血清和人乳抗菌抗体滴度，以测试营养不良是否与分泌性抗体反应受损有特定关联。将营养不良妇女与对照妇女进行比较时，未检测到血清和人乳总免疫球蛋白浓度、抗轮状病毒中和抗体滴度或抗轮状病毒、呼吸道合胞病毒、大肠杆菌、肺炎链球菌和流感嗜血杆菌的特异性酶联免疫吸附测定抗体滴度有降低。营养不良对扎伊尔妇女的循环和分泌抗体浓度没有影响。然而，营养不良妇女的每日人乳产量比对照妇女低约30%，导致营养不良妇女的孩子摄入的免疫球蛋白相应减少。
