Sivitz W I
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa College of Medicine, Iowa City, USA.
Postgrad Med. 2001 Apr;109(4):55-9, 63-4. doi: 10.3810/pgm.2001.04.908.
Excess fat, excess glucose, or both act on diverse cells and tissues to counteract insulin-mediated glucose uptake, hepatic regulation of glucose output, and insulin secretion. These effects are labeled lipotoxicity and glucotoxicity because, when severe enough, each may contribute to the diabetic state. Lifestyle modifications and certain new pharmacologic agents may be effective in modulating these effects and could prove useful in primary prevention of type 2 diabetes.
过多的脂肪、过多的葡萄糖或两者共同作用于多种细胞和组织，以对抗胰岛素介导的葡萄糖摄取、肝脏对葡萄糖输出的调节以及胰岛素分泌。这些效应被称为脂毒性和糖毒性，因为当严重到一定程度时，每一种都可能导致糖尿病状态。生活方式的改变和某些新型药物制剂可能有效地调节这些效应，并可能在2型糖尿病的一级预防中发挥作用。
