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前瞻性膳食自由基清除剂:在药代动力学方面是福音,在糖尿病等代谢紊乱障碍期间,通过信号级联克服胰岛素吸收障碍。

Prospective dietary radical scavengers: Boon in Pharmacokinetics, overcome insulin obstruction via signaling cascade for absorption during impediments in metabolic disorder like Diabetic Mellitus.

作者信息

Suresh Varuna, Kunnath John, Reddy Amala

机构信息

Animal Cell Culture Laboratory, Department of Biotechnology, SRMIST, Kancheepuram district, Kattankulathur, 603203 Tamilnadu India.

出版信息

J Diabetes Metab Disord. 2022 Apr 21;21(1):1149-1169. doi: 10.1007/s40200-022-01038-8. eCollection 2022 Jun.

Abstract

Diabetes mellitus is a metabolic disorder which is characterized based on the blood glucose level. This can be due to the lack of efficiency of utilizing insulin or lack of production of insulin. There are numerous therapies and medications which are available for the treatment of this disease which can reduce the risk of diabetes. But there is no permanent cure found. Nutritional antioxidants show a foremost role in sustaining the homeostasis of the oxidative equilibrium. They have imparted their electron donor efficacy in preventing aging and in cancer. Vitamin C, E, β-carotene, carotenoids, polyphenols and selenium have been appraised as antioxidant constituents in the human diet nourishment. This paper emphasizes on the role of antioxidants which help in reducing or maintaining the level of glucose in the body. Antioxidants are substances that reduces the damages to the cells caused by free radicals. The available treatment and medications and how the supplementation of antioxidants is different from them is also discussed. Different type of antioxidants and their treatment in curing the disease is further focused in this paper.

摘要

糖尿病是一种基于血糖水平特征的代谢紊乱疾病。这可能是由于胰岛素利用效率低下或胰岛素分泌不足所致。有许多疗法和药物可用于治疗这种疾病,从而降低糖尿病风险。但尚未找到永久性治愈方法。营养抗氧化剂在维持氧化平衡的内稳态中发挥着首要作用。它们在预防衰老和癌症方面展现出电子供体功效。维生素C、E、β-胡萝卜素、类胡萝卜素、多酚和硒已被评估为人类饮食营养中的抗氧化成分。本文着重探讨抗氧化剂在降低或维持体内血糖水平方面的作用。抗氧化剂是减少自由基对细胞造成损伤的物质。还讨论了现有的治疗方法和药物,以及抗氧化剂补充与它们的不同之处。本文进一步聚焦于不同类型的抗氧化剂及其在治疗该疾病中的作用。

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Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus.2型糖尿病患者补充辅酶Q10
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