Jackson M A, Ahluwalia B S, Attah E B, Connolly C A, Herson J, Heshmat M Y, Jackson A G, Jones G W, Kapoor S K, Kennedy J, Kovi J, Lucas A O, Nkposong E O, Olisa E, Williams A O
Cancer Chemother Rep. 1975 Jan-Feb;59(1):3-15.
This study was designed to compare United States (Washington, DC) black prostatic carcinoma patients (high-risk group) with Nigerian (Ibadan) black prostatic carcinoma patients (low-risk group). Although the material is meager, preliminary analyses suggest that carcinoma of the prostate is a common disease in both US black men (196 of 1000 autopsies) and in Nigerian black men (67 of 1000 autopsies). The tumor tends to be of a higher histologic grade (less well differentiated) and the carcinomatous foci are more numerous in the Nigerian patients. Fifty-three percent of US patients are in stages I and II when the disease is first discovered. Plasma testosterone, estrone, and estradiol concentrations did not differ significantly between US patients and controls. A statistically significant positive association is indicated between carcinoma of the prostate and the following epidemiologic variables: racial admixture, age of puberty, and age of first coitus. The median age of necropsy cases with carcinoma was 50.0 years in Nigeria and 68.3 years in the US.
本研究旨在比较美国（华盛顿特区）黑人前列腺癌患者（高危组）与尼日利亚（伊巴丹）黑人前列腺癌患者（低危组）。尽管资料有限，但初步分析表明，前列腺癌在美国黑人男性（每1000例尸检中有196例）和尼日利亚黑人男性（每1000例尸检中有67例）中都是一种常见疾病。尼日利亚患者的肿瘤往往组织学分级较高（分化较差），癌灶更多。美国患者中53%在疾病首次发现时处于I期和II期。美国患者与对照组之间的血浆睾酮、雌酮和雌二醇浓度无显著差异。前列腺癌与以下流行病学变量之间存在统计学上显著的正相关：种族混合、青春期年龄和首次性交年龄。尼日利亚尸检病例中患癌者的中位年龄为50.0岁，美国为68.3岁。
